The selection of the risk genes

How are the genes selected?

The scientific literature already identifies a large number of genes that are associated with diseases, but in many cases, it was not possible to scientifically verify these associations. In other cases, although a significant statistical link exists, the influence of a possible genetic defect on the disease risk is too low to justify a genetic analysis only for precautionary purposes. After a rigorous selection of the potential risk genes, there remain for example, 16 possible genes left connected with thrombosis. In each of these genes, several defects have already been discovered; these defects were linked with the increased risk of thrombosis, based on scientific studies conducted in collaboration with thrombosis patients.

From these genes, only those genes were selected, which carry sufficient genetic defects in the European population to warrant genetic testing. Genes that, for example, trigger a defect in only one of 20.000 people, were deliberately not included in our program, because they cannot justify a genetic testing. It was also checked, for each gene, whether genetic defects in these genes also sufficiently increase the risk to justify such an action.

According to these strict selection criteria, all relevant risk genes were selected and included in our program. Therefore, the public health reports speak only of the genes relevant for the health care.



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